Troy Larson sent me a heads up on Bit9's FileAdvisor, a service they describe as "a comprehensive catalog of executables, drivers, and patches found in commercial Windows applications and software packages. Malware and other unauthorized software that affects Windows computers is also indexed."
I immediately checked the FileAdvisor db for malware results as well non-Windows binaries and was pleasantly surprised with immediate and comprehensive results. You do have to register, but I was further impressed with the fact that they offered the option for a short or full registration.
This appears to be worthy of a bookmark in your incident handler/malware researcher/forensic investigator toolkit.

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